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KMID : 1134820110400060824
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 6 p.824 ~ p.831
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Oral Toxicity Study on the 90-day Repeated-dose of 50 kGy Irradiated Methanol Extract Powder of Red Ginseng
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Jeon Young-Eun
Kim Jin-Kyung
Yin Xing-Fu
Lee Ju-Woon
Nam Jin-Sik
Kang Il-Jun
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Abstract
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This study was to investigate 90-day repeated-dose toxicities of 50 kGy irradiated methanol extract powder of red ginseng in ICR mice. The test materials (methanol extract powder of red ginseng with or without 50 kGy irradiation) were administered by gavage to male and female ICR mice at dose levels of 0, 125, 250 and 500 ㎎/㎏/day for 90 days. In the results, no abnormality was observed in mortality, clinical findings, body weight changes, food consumptions, ophthalmoscopic findings, necropsy findings and histopathological findings. Although the minor changes in blood and biochemical parameters were observed, they were not dose dependent and not affected by gamma irradiation. In conclusion, 90-day repeated oral dose of the methanol extract powder of red ginseng and 50 kGy irradiated methanol extract powder of red ginseng to ICR mice did not cause apparent toxicological change at the dose of 125, 250 and 500 ㎎/㎏ body weight.
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KEYWORD
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red ginseng, gamma irradiation, 90-day repeated-dose oral toxity
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